How a critical enzyme keeps potentially dangerous genes in check
Meet OGT, your guardian enzyme on the dark side of the genome
Research Center Center for Cancer Immunotherapy
LJI scientists receive Curebound funding to advance cancer research
Curebound grants may lead to new approaches to fight breast cancer, lung tumors and more
T cells rise up to fight infections in the gut
Scientists show how a special group of T cells travels through the small intestine to combat pathogens
Cancer researcher Miguel Reina-Campos awarded $1.3 million from W. M. Keck Foundation
LJI lab looks to "boost" cancer-fighting T cells
New Prebys Foundation grant supports LJI mission to train the next generation of researchers
With this new $300,000 grant, LJI Assistant Professor Miguel Reina-Campos, Ph.D., sets out to make scientific training more accessible
Vijayanand Lab
Pandurangan Vijayanand, M.D., Ph.D., and his lab members employ genomics tools to understand, diagnose and treat pulmonary disease such as asthma, lung cancer and infectious diseases, including the novel coronavirus.
Sharma Lab
Sonia Sharma, Ph.D., and her lab members lead unbiased, genome-scale approaches to unravel innate immunity, the body’s early immune response to microbial pathogens and neoplastic cells.
Sette Lab
Alessandro Sette, Dr.Biol.Sci., defines in chemical terms the specific structures (epitopes) that the immune system recognizes and uses this knowledge to measure and understand immune responses.
Schoenberger Lab
Stephen Schoenberger, Ph.D., is focused on achieving a mechanistic understanding of the generation and regulation of T cell responses in the context of in vivo infection and tumor development.
Saphire Lab
Erica Ollmann Saphire, Ph.D., MBA, studies, at the molecular level, how and why viruses are pathogenic. This work provides the roadmap for medical defense.
Rao Lab
Anjana Rao, Ph.D., focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.
Peters Lab
Bjoern Peters, Ph.D., and his lab members are focused on the development of computational tools to address fundamental questions in immunology.
Hogan Lab
Patrick Hogan, Ph.D., studies cells at the nano level – seeking to understand how protein-protein interactions on the submicroscopic scale can have gargantuan impacts on human health and disease.
Cheroutre Lab
Hilde Cheroutre, Ph.D., and her team study the development, function, and regulation of T lymphocytes, a type of white blood cells.
LJI selected as member of ARPA-H Investor Catalyst Hub Spoke Network
LJI joins a nationwide network working to accelerate transformative health solutions
Lung Cancer
Lung cancer is the leading cause of cancer death for both men and women in the United States. Researchers at La Jolla Institute for Immunology are studying ways to halt lung cancer growth.
Cancer
Scientists in LJI’s Center for Cancer Immunotherapy are committed to making cancer immunotherapies work for more people.
Reina Lab
Dr. Reina-Campos’ lab seeks to understand the underlying principles governing tissue immune networks that enable robust and long-term protection against infection and tumors.
Ay Lab
Ferhat Ay, Ph.D., works to understand gene regulation in complex organisms and diseases.
LJI scientists develop new method to match genes to their molecular ‘switches’
New research may help scientists hunt down solid tumors and better diagnose disease
Researchers reveal how protein modifications power T cells
LJI scientists share a new, rapid method for studying phosphorylation and other post-translational modifications
LJI home to new “Center of Excellence”
LJI's Flow Cytometry Core brings cutting-edge technology to immune system researchers
A step toward personalized immunotherapy for all
Scientists find evidence that all cancer patients mount an immune response to their tumors, suggesting that many more patients could benefit from personalized immunotherapy
Researchers discover potentially cancer-fighting T cells within some pediatric brain tumor patients
New research suggests a small group of pediatric brain tumor patients may benefit from immunotherapy
On the trail of missing genes and cancer clues
LJI scientists connect TET loss of function to missing genes in embryonic stem cells
Six LJI scientists named “Highly Cited Researchers”
The international recognition reflects how LJI research is valued by scientific peers
Lynn Hedrick and Klaus Ley named “World Experts” in monocyte research
Immune cells called monocytes offer clues to treating cancers, heart disease and more
Preparing T cells for the long haul
New LJI research could keep cancer-fighting T cells from burning out before the job is done
Many cancer patients may need a sequential one-two punch of immunotherapies
Treating patients with anti-CTLA4 therapies prior to anti-PD1 treatment may be a promising strategy
Sonia Sharma zeros in on metabolites
The mission is simple: Figure out which key molecules go missing in cancer patients.
Timothy Baffi receives ACS award to study acute myeloid leukemia
New support from the American Cancer Society fuels research into the primary mutations behind many cancer types
LJI launches new global cancer immunology resource
National Cancer Institute support brings cancer researchers together to share key findings
Learning from men. Learning from women.
Men and women have different immune systems. With a better understanding of sex-specific immune differences, scientists can more effectively fight infections, cancers, heart disease, and even pregnancy complications.
Amnon Altman: Leading immunologist and educator retires
Dr. Altman’s research into T cell activation opened the door to new therapies for inflammation, autoimmune diseases, cancers, and more.
Melanoma meets its match
How Ian Mathews used Tullie and Rickey Families SPARK Awards funding to make cancer therapy advances and launch a career in medicine
A clue to how some fast-growing tumors hide in plain sight
New LJI research could guide the development of more effective cancer immunotherapies
The Conrad Prebys Foundation grants more than $450,000 for studies into childhood cancer, cardiovascular disease
New funding will support high-risk, high-reward projects led by two early-career scientists
A cancer without a cause
Testing for breast and ovarian cancers has come a long way—but at-risk patients still fall through the cracks. LJI scientist Anup Kumar Singh has won funding to learn more about cancer-causing mutations.
Proteomics expert Sam Myers to join LJI faculty
Myers Lab to expand autoimmune disease research, cancer and more
New 3D maps reveal inner workings of immune cell gene expression
LJI scientists track down control elements that govern gene expression from a distance
Inside the labs of three leading San Diego scientists
LJI Professors Shane Crotty, Ph.D., Bjoern Peters, Ph.D., and Alessandro Sette, Dr. Biol. Sci., were named “Highly Cited Researchers” this week by Clarivate.
LJI team gets first-ever look at a rare but vital stem cell in humans
New understanding of immune cell origins may offer cancer and COVID-19 drug targets
LJI donors turn health crisis into mission to champion Institute’s new cancer vaccine
Sometimes it takes a personal health crisis to galvanize people to pursue a life-changing path they could have never envisioned.
TET proteins: double agents in DNA methylation prevent catastrophic cancer
LJI researchers reveal how the finely tuned balance between DNA methylation and demethylation prevents genomic instability and cancer
To kill tumors, activate this elite group of T cells
LJI’s new understanding of killer T cells inspires clinical studies of potential immunotherapies
To respond or tolerate? LJI researchers selectively block immune activation program orchestrated by the nuclear factor NFAT
Chemical screen proves feasibility of modulating factor at the hub of immune system's decision to attack or retreat
Scientists devise strategies to counteract T cell exhaustion in CAR T cancer therapies
La Jolla Institute scientists show that deleting troublesome proteins in a mouse model can shrink tumors and prolong survival
