T cells take aim at Chikungunya virus
As Chikungunya spreads into new regions, LJI scientists share a first look at how human T cells target the virus. Their findings may shed light on how viruses can trigger chronic disease.
Research Center Center for Autoimmunity and Inflammation
A new timeline for Parkinson’s disease
LJI scientists discover that T cells may allow for early detection of Parkinson's cases—years before motor symptoms development.
Carolyn Moderbacher hunts down rogue immune cells
Moderbacher wins funding from the Lupus Research Alliance to investigate lupus from a new angle
How a critical enzyme keeps potentially dangerous genes in check
Meet OGT, your guardian enzyme on the dark side of the genome
The Decision Makers | Dr. Sam Myers x Global Autoimmune Institute
See how investment in science is reshaping the landscape of autoimmune disease research
Stopping asthma in its tracks
New therapeutic "cocktails" may provide long-lasting relief for treatment-resistant asthma and other immune system inflammatory diseases.
Job Rocha awarded BioLegend Graduate Fellowship in Immunology
Rocha aims to understand a devastating liver disease
LJI researchers shed light on devastating blood diseases
Scientists show how a mutated gene harms red and white blood cells
Global Autoimmune Institute invests over $800,000 in La Jolla Institute for Immunology, strengthening autoimmune disease research and patient resources
"We are grateful for this opportunity to deepen our collaboration with such an influential partner in autoimmune research."
LJI launches “America’s SHIELD” to develop life-saving herpesvirus vaccines
San Diego laboratories lead vaccine innovation research through new ARPA-H program
Vijayanand Lab
Pandurangan Vijayanand, M.D., Ph.D., and his lab members employ genomics tools to understand, diagnose and treat pulmonary disease such as asthma, lung cancer and infectious diseases, including the novel coronavirus.
Sharma Lab
Sonia Sharma, Ph.D., and her lab members lead unbiased, genome-scale approaches to unravel innate immunity, the body’s early immune response to microbial pathogens and neoplastic cells.
Sette Lab
Alessandro Sette, Dr.Biol.Sci., defines in chemical terms the specific structures (epitopes) that the immune system recognizes and uses this knowledge to measure and understand immune responses.
Schoenberger Lab
Stephen Schoenberger, Ph.D., is focused on achieving a mechanistic understanding of the generation and regulation of T cell responses in the context of in vivo infection and tumor development.
Schmiedel Lab
Dr. Schmiedel is dedicated to shedding light on the genetic mechanisms driving the pathogenesis of human diseases. His research is revealing molecular features regulating immune cell function to enhance our understanding and advance disease diagnosis, treatment, and prevention.
Saphire Lab
Erica Ollmann Saphire, Ph.D., MBA, studies, at the molecular level, how and why viruses are pathogenic. This work provides the roadmap for medical defense.
Rao Lab
Anjana Rao, Ph.D., focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.
Myers Lab
Samuel Myers, Ph.D., studies the signaling circuits that drive the behavior of individual immune cells and ultimately orchestrate systemic immune responses.
Kronenberg Lab
Mitchell Kronenberg, Ph.D., and his team study T cells – white blood cells responsible for recognizing and responding to foreign invaders, such as microbes.
Hogan Lab
Patrick Hogan, Ph.D., studies cells at the nano level – seeking to understand how protein-protein interactions on the submicroscopic scale can have gargantuan impacts on human health and disease.
Croft Lab
Michael Croft, Ph.D., and his team focus on a number of molecules that are members of the tumor necrosis factor (TNF) and tumor necrosis factor receptor (TNFR) family.
Cheroutre Lab
Hilde Cheroutre, Ph.D., and her team study the development, function, and regulation of T lymphocytes, a type of white blood cells.
LJI selected as member of ARPA-H Investor Catalyst Hub Spoke Network
LJI joins a nationwide network working to accelerate transformative health solutions
Vasculitis
Vasculitis is the umbrella term for nearly 20 rare diseases all associated with inflammation of the blood vessels.
Seasonal Allergies
Millions of people suffer from seasonal allergies. For them, the onset of spring signals several months of misery.
Parkinson’s Disease
Researchers at La Jolla Institute are investigating how the immune system may contribute to Parkinson's disease.
Inflammatory bowel disease
Researchers at La Jolla Institute are working to prevent the symptoms of IBD before inflammation escalates.
Food Allergies
Allergens like egg, shellfish, or peanut proteins stimulate white blood cells to dump excessive quantities of immune molecules into the blood, triggering inflammation.
Fibrosis
Fibrosis occurs when immune cells mistakenly attack these connective tissues, causing the tissues to thicken and scar.
Autoimmune Disease
Scientists at La Jolla Institute are investigating what causes immune cells to turn on the body—and how we can intervene.
Atopic Dermatitis / Eczema
Atopic dermatitis occurs when a person’s immune system causes inflammation of the skin, which also makes the skin more vulnerable to environmental irritants and allergens.
Heart Disease
Heart disease, also called cardiovascular disease, can describe several conditions, including coronary artery disease and aortic athlerosclerosis.
Asthma
Asthma affects more than 25 million people across the nation—7 million of them children—and the incidence is rising.
Allergies
Conditions such as eczema, contact dermatitis, allergy-induced asthma and hay fever are all connected to allergy.
New research points to ‘stem-like’ T cells as culprits in ulcerative colitis
LJI scientists zero in on T cells that may drive autoimmune disease in human patients
Reina Lab
Dr. Reina-Campos’ lab seeks to understand the underlying principles governing tissue immune networks that enable robust and long-term protection against infection and tumors.
Benedict Lab
Christopher Benedict, Ph.D., studies the strategies that viruses use to escape detection by our immune system.
Ay Lab
Ferhat Ay, Ph.D., works to understand gene regulation in complex organisms and diseases.
Hilde Cheroutre named AAI Distinguished Fellow
Leading immunologist honored for research into the roots of autoimmunity, cancer development, and more
Researchers reveal how protein modifications power T cells
LJI scientists share a new, rapid method for studying phosphorylation and other post-translational modifications
LJI home to new “Center of Excellence”
LJI's Flow Cytometry Core brings cutting-edge technology to immune system researchers
Blocking immune system ‘messenger’ may treat severe asthma
Finally beating asthma might hinge on blocking HRF and IgE interactions
Lasting relief may be on the horizon for patients with atopic dermatitis
LJI research collaboration with Kyowa Kirin Co., Ltd., points to a novel approach to treat the most common form of eczema
Origin story: How T cell heroes and villains are made
LJI Postdoctoral Fellow Greet Verstichel on how T cells learn their "fate"
Scientists uncover new targets for treating Parkinson’s disease
LJI study suggests therapies could stop T cells from attacking brain cells in Parkinson's
LJI team uncovers new subsets of CD4+ ‘helper’ T cells
New analysis shows men and women really do have immune cell differences
New research gets to the roots of type 1 diabetes
A Q&A with Estefania Quesada-Masachs, M.D., Ph.D.
WHAM and La Jolla Institute for Immunology identify economic imperative of research focused on women, partner to accelerate autoimmune research focused on women
New study shows autoimmune rheumatoid arthritis research focused on women will bring billions to the economy. Leading immune research institute announces new sex and gender focus.
Partial bone marrow transplant ‘rescues’ mice with cystic fibrosis
New bone marrow gives sick mice healthy monocytes
Macrophages in the artery wall ‘smell’ their surroundings
Immune cells can sniff out octanal in blood, triggering dangerous inflammation and atherosclerosis
Suffering from psoriasis? Blame this trio of proteins
New LJI study shows there may be a way to help even more psoriasis patients
Six LJI scientists named “Highly Cited Researchers”
The international recognition reflects how LJI research is valued by scientific peers
LJI graduate students win prestigious ARCS San Diego awards
ARCS support propels vaccine design and HIV research
When Alex Marki sets sail
After a long week in the lab, Sundays are for sailing
Lynn Hedrick and Klaus Ley named “World Experts” in monocyte research
Immune cells called monocytes offer clues to treating cancers, heart disease and more
Hard-working enzyme keeps immune cells in line
LJI scientists develop new tool for understanding enzymatic activity linked to blood cancers and heart disease
A new window into autoimmune diseases
LJI scientists uncover coordinated immune cell activity as a driver of systemic lupus erythematosus
Learning from men. Learning from women.
Men and women have different immune systems. With a better understanding of sex-specific immune differences, scientists can more effectively fight infections, cancers, heart disease, and even pregnancy complications.
Unmasking the pancreas
No one knows exactly what triggers type 1 diabetes, but researchers at La Jolla Institute for Immunology have uncovered some fascinating clues.
The Conrad Prebys Foundation grants more than $450,000 for studies into childhood cancer, cardiovascular disease
New funding will support high-risk, high-reward projects led by two early-career scientists
LJI research leads to promising combination therapy for type 1 diabetes
Phase 2 trial run by Novo Nordisk emphasizes the importance of translational research
Proteomics expert Sam Myers to join LJI faculty
Myers Lab to expand autoimmune disease research, cancer and more
The story behind a vivid pancreas image
"To prevent and treat the disease, it is vital to understand how the immune cells attack the body's own insulin-producing beta cells"
LJI asthma researcher Jermaine Khumalo receives AAI Intersect Fellowship
New fellowship will support data science and immunology cross-training in two pioneering LJI labs
New 3D maps reveal inner workings of immune cell gene expression
LJI scientists track down control elements that govern gene expression from a distance
Inside the labs of three leading San Diego scientists
LJI Professors Shane Crotty, Ph.D., Bjoern Peters, Ph.D., and Alessandro Sette, Dr. Biol. Sci., were named “Highly Cited Researchers” this week by Clarivate.
New study points to a better way to ward off asthma triggers
LJI study suggests future asthma therapies need to target two key immune molecules
Klaus Ley receives $2.3 Million to study fundamentals of immune cell activation
New research could shed light on how immune cells can better fight cancers or step back in autoimmune disease
Diabetes researchers spot dangerous T cells in the pancreas—even in healthy people
LA JOLLA—Your pancreas is studded with cell clusters called islets. In most people, special beta cells live snug in the islets, happily making the insulin that the body uses to regulate blood sugar. But in people with type 1 diabetes,…
A step toward helping patients breathe deeply
LJI scientists track down a protein that may add to lung damage in asthma and related diseases
LJI scientists receive $3.5 million to investigate role of immune cells in Parkinson’s disease
More than 930,000 Americans are living with Parkinson's disease
Blocking nerve signals to the pancreas halts type 1 diabetes onset in mice
New LJI discovery could help explain patterns of cell death in many autoimmune diseases
T cells can shift from helping to harming in atherosclerosis
LJI study brings scientists closer to designing a safe anti-atherosclerosis vaccine
Researchers track down metabolic enzyme that protects against inflammation
LJI study shows new link between metabolism and the immune system
LJI scientists investigate a powerful protein behind antibody development
The new study shows how a protein works as a “master regulator” in the immune system
LJI scientists uncover immune cells that may lower airway allergy and asthma risk
Study opens up new path to research to fighting allergic diseases
LJI scientists link immune cells to Parkinson’s Disease onset
New research gives further evidence that autoimmunity plays a role in Parkinson’s disease
Too much haste leads to little speed
Newly discovered biological switch evolved to stimulate the immune system—can also lead to immune paralysis
iMAP of human atherosclerosis shortlisted for £30m research prize
The proposed iMAP will reveal new targets for immunotherapy, and may lead to a new wave of medicines and vaccines that can prevent heart attacks and strokes; La Jolla Institute for Immunology researcher Klaus Ley and Scripps researcher Eric Topol are key members of the iMAP team.
Seqster Signs 3-year License Agreement of SRP™ to La Jolla Institute of Immunology for Asthma Study
Seqster research portal empowers study participants to instantly collect & share medical records and genomic data with researchers
TET gene mutations in T regulatory cells unleash fatal autoimmune disease in mice
New study reveals how a subset of T cells morphs from peacemaker to rabble-rouser when TET activity is lost
Dr. Mitchell Kronenberg elected Distinguished Fellow by the American Association of Immunologists
Dr. Kronenberg is among 52 immunologists, including five Nobel Laureates, selected for the inaugural class of fellows
